ARG57245

anti-CD321 / JAM1 antibody [RM275]

anti-CD321 / JAM1 antibody [RM275] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

概述

产品描述 Rabbit Monoclonal antibody [RM275] recognizes CD321 / JAM1
反应物种 Hu
应用 IHC-P, WB
特异性 This antibody reacts to Human JAM1 (Junctional adhesion molecule 1).
宿主 Rabbit
克隆 Monoclonal
克隆号 RM275
同位型 IgG
靶点名称 CD321 / JAM1
抗原物种 Human
抗原 Synthetic peptide around the N-terminus of Human CD321 / JAM1.
偶联标记 Un-conjugated
全名 F11 receptor
別名 JAM-1; JAM1; Junctional adhesion molecule A; CD antigen CD321; JCAM; JAM-A; Junctional adhesion molecule 1; PAM-1; JAM; JAMA; KAT; Platelet F11 receptor; Platelet adhesion molecule 1; CD321

应用说明

应用建议
应用 推荐稀释比
IHC-P1:2000 - 1:10000
WB1:250 - 1:1000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
预测分子量 33 kDa

属性

形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.09% Sodium azide, 50% Glycerol and 1% BSA.
抗菌剂 0.09% Sodium azide
稳定剂 50% Glycerol and 1% BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 50848 Human F11R

Swiss-port # Q9Y624 Human Junctional adhesion molecule A

基因名称 F11R
基因全名 F11 receptor
背景介绍 Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
生物功能 Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. [UniProt]
翻译后修饰 N-glycosylated.

检测图片 (2) Click the Picture to Zoom In

  • ARG57245 anti-CD321 / JAM1 antibody [RM275] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human kidney tissue sections stained with ARG57245 anti-CD321 / JAM1 antibody [RM275] at 1:10000 dilution.

  • ARG57245 anti-CD321 / JAM1 antibody [RM275] WB image

    Western blot: HEK293 cell lysates stained with ARG57245 anti-CD321 / JAM1 antibody [RM275] at 1:250 dilution.