ARG30037

Phospho IKB alpha Antibody Duo (Total, pS32/36)

Cancer antibody; Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody
publication_link 参考文献2

内含物

货号 内含物名称 宿主克隆性 反应 应用 包装
ARG51651 anti-IKB alpha phospho (Ser32 / Ser36) antibody Rabbit pAb Hu, Ms, Rat ICC/IF, IHC-P, WB 50 μl
ARG54059 anti-IkB alpha antibody (N-term) Mouse mAb Hu, Ms, Rat WB 50 μl

概述

产品描述

IκB-α inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, triggers IκB-α phosphorylated at Ser32/36 and promotes IκB-α ubiquitination and degradation, enabling the dimeric NFkB to translocate to the nucleus and activate transcription.

ARG30037 IκB-α phospho Duos (Total, pS32/36), includes an antibody reacts total IκB-α protein and an antibody recognizes IκB-α only when Ser32/36 of IκB-α is phosphorylated. This antibody Duos could be used in evaluation of total or Ser32/36 phosphorylated IκB-α protein in IκB-α/NFkB signaling and IκB-α/NFkB regulation studies.

靶点名称 IKB alpha
別名 Phospho IKB alpha antibody; Phospho nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha antibody; IKB alpha phospho (Ser32 / Ser36) antibody; IkB alpha antibody (N-term)

属性

存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

全名 Phospho nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IKB alpha) Antibody Duo (Total, pS32/36)
研究领域 Cancer antibody; Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody

检测图片 (4) Click the Picture to Zoom In

  • ARG51651 anti-IKB alpha phospho (Ser32/Ser36) antibody WB image

    Western Blot: extracts from HeLa cells untreated or treated with TNF stained with anti-I kappa B alpha (phospho Ser32/Ser36) antibody ARG51651.

  • ARG51651 anti-IKB alpha phospho (Ser32/Ser36) antibody IHC-P image

    Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-I kappa B alpha (phospho Ser32/Ser36) antibody ARG51651 (left) or the same antibody preincubated with blocking peptide (right).

  • ARG51651 anti-IKB alpha phospho (Ser32/Ser36) antibody ICC/IF image

    Immunofluorescence: methanol-fixed HeLa cells stained with anti-I kappa B alpha (phospho Ser32/Ser36) antibody ARG51651.

  • ARG54059 anti-IkB alpha antibody (N-term) WB image

    Western blot: 3T3 cell lysate stained with ARG54059 anti-IkB alpha antibody (N-term) at 1:500 dilution.

文献引用

Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury

ARG51651, ARG54059: WB / Human

Yuhua Zhou et al.
Cent Eur J Immunol .,  (2022)

publication_link

 

hr_line

Effects and mechanisms of PSS-loaded nanoparticles on coronary microcirculation dysfunction in streptozotocin-induced diabetic cardiomyopathy rats.

ARG51651, ARG54059: WB / Rat

Mao Yongjun et al.
Biomed Pharmacother.,  (2019)

publication_link

 

hr_line