ARG44250
anti-PTPN22 antibody
anti-PTPN22 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Chimpanzee
概述
| 产品描述 | Goat Polyclonal antibody recognizes PTPN22 |
|---|---|
| 反应物种 | Hu, Chimp |
| 应用 | FACS, ICC/IF, IHC-P |
| 特异性 | This antibody is specific for human LYP1 and will not cross to LYP2 |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PTPN22 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human PTPN22 (CPPNKPAESVQSNNS) |
| 偶联标记 | Un-conjugated |
| 別名 | LYP1; Lymphoid phosphatase; LYP2; LYP; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; PEP; PTPN8; Tyrosine-protein phosphatase non-receptor type 22; PEST-domain phosphatase; LyP; EC 3.1.3.48 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y2R2 Human Tyrosine-protein phosphatase non-receptor type 22 |
|---|---|
| 基因名称 | PTPN22 |
| 全名 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) |
| 背景介绍 | This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009] |
| 生物功能 | Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 92 kDa |
| 翻译后修饰 | Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG44250 anti-PTPN22 antibody IHC-P image
Immunohistochemistry: Human Small Intestine stained with ARG44250 anti-PTPN22 antibody at 3.75µg/ml dilution.
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ARG44250 anti-PTPN22 antibody ICC/IF image
Immunofluorescence: U2OS stained with ARG44250 anti-PTPN22 antibody at 10µg/ml dilution.
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ARG44250 anti-PTPN22 antibody FACS image
Flow Cytometry: Jurkat stained with ARG44250 anti-PTPN22 antibody at 10µg/ml dilution.
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ARG44250 anti-PTPN22 antibody IHC-P image
Immunohistochemistry: Human Adrenal Gland stained with ARG44250 anti-PTPN22 antibody at 3.75µg/ml dilution.
