ARG67042

anti-NTRK2 antibody [SQab30321]

anti-NTRK2 antibody [SQab30321] for IHC-Formalin-fixed paraffin-embedded sections and Human

概述

产品描述 Recombinant rabbit Monoclonal antibody [SQab30321] recognizes NTRK2
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab30321
同位型 IgG
靶点名称 NTRK2
抗原物种 Human
抗原 Synthetic peptide of Human TRK2.
偶联标记 Un-conjugated
Protein Full name BDNF/NT-3 growth factors receptor
別名 NTRK2, Neurotrophic Receptor Tyrosine Kinase 2, TRKB, BDNF/NT-3 Growth Factors Receptor, Neurotrophic Tyrosine Kinase Receptor Type 2, Tropomyosin-Related Kinase B, EC 2.7.10.1, GP145-TrkB, Trk-B, Neurotrophic Tyrosine Kinase, Receptor, Type 2, BDNF-Tropomyosine Receptor Kinase B, Tyrosine Kinase Receptor B, TrkB Tyrosine Kinase, EC 2.7.10, EIEE58, DEE58, OBHD

应用说明

应用建议
应用 推荐稀释比
IHC-P1:50 - 1:100
应用说明 The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Human brain

属性

形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05%BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 4915 Human NTRK2

Swiss-port # Q16620 Human BDNF/NT-3 growth factors receptor

基因名称 NTRK2
全名 Neurotrophic Receptor Tyrosine Kinase 2
背景介绍 This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
生物功能 Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. [Uniprot]
细胞定位 Cell membrane, Cell projection, Cytoplasm, Endosome, Membrane, Synapse
预测分子量 92 kDa
翻译后修饰 Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated. Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG67042 anti-NTRK2 antibody [SQab30321] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded human brain tissue stained with ARG67042 anti-NTRK2 antibody [SQab30321].