anti-MyD88 antibody [SQab30311]

anti-MyD88 antibody [SQab30311] for IHC-Formalin-fixed paraffin-embedded sections and Human


产品描述 Recombinant rabbit Monoclonal antibody [SQab30311] recognizes MyD88
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab30311
同位型 IgG
靶点名称 MyD88
抗原物种 Human
抗原 Synthetic peptide of Human MyD88 .
偶联标记 Un-conjugated
Protein Full name Myeloid differentiation primary response protein MyD88
別名 MYD88, MYD88 Innate Immune Signal Transduction Adaptor, Myeloid Differentiation Primary Response Protein MyD88, Myeloid Differentiation Primary Response Gene (88), Myeloid Differentiation Primary Response 88, TLR Adaptor MYD88, Mutant Myeloid Differentiation Primary Response 88, MYD88D, IMD68


应用 推荐稀释比
IHC-P1:50 - 1:100
应用说明 IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 32 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 MYD88, L265P, HEK293


形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05%BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.


基因名称 MyD88
全名 MYD88 Innate Immune Signal Transduction Adaptor
背景介绍 This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
生物功能 Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation. [Uniprot]
预测分子量 33 kDa
翻译后修饰 Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG67041 anti-MyD88 antibody [SQab30311] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded HEK293 stained with ARG67041 anti-MyD88 antibody [SQab30311].