anti-CD11b antibody [3A33] (PE-Cy7)

anti-CD11b antibody [3A33] (PE-Cy7) for Flow cytometry,ICC/IF,Blocking and Mouse


产品描述 PE-Cy7-conjugated Rat Monoclonal antibody [3A33] recognizes CD11b
反应物种 Ms
特异性 Mouse CD11b.
宿主 Rat
克隆 Monoclonal
克隆号 3A33
同位型 IgG2aκ
靶点名称 CD11b
抗原物种 Mouse
抗原 Peritoneal macrophages from B6D2 hybrid mice
偶联标记 PE-Cy7
全名 integrin, alpha M (complement component 3 receptor 3 subunit)
別名 MAC1A; CR3A; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Integrin alpha-M; MAC-1; CD11 antigen-like family member B; Leukocyte adhesion receptor MO1; MO1A; SLEB6; Neutrophil adherence receptor; CD antigen CD11b; CD11B


应用 推荐稀释比
FACS< 0.3 µg/10^6 cells
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


形式 Liquid
缓冲液 PBS, Sodium azide and a stabilizing agent
抗菌剂 Sodium azide
浓度 0.1 mg/ml
存放说明 Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 16409 Mouse ITGAM

基因名称 ITGAM
基因全名 integrin, alpha M (complement component 3 receptor 3 subunit)
背景介绍 This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
生物功能 Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. [UniProt]